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Anabolic-androgenic steroids can cause or exacerbate CKD and also kidney fibrosis or sclerosis with different mechanisms: Renal blood pressure regulation. Since androgen receptors are located in different parts of the kidney and on the other hand, various enzymes involved in testosterone synthesis pathway are produced in the kidney tissue, it is conceivable that testosterone is able to regulate renal artery blood pressure (BP) [27]. Testosterone can increase renal artery BP, probably via potentiating the renin’angiotensin-aldosterone system (RAAS) along with the up-regulation of endothelin, .

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